| Sencillo | | Nueva Segovia vs. Masaya | | 11:00 a.m. | | 21/4/21 | | | |
| J1 | | Costa Caribe vs. Granada | | 01:00 p.m | | 28/4/21 | | | |
| J2 | | Costa Caribe vs. Granada | | 05:00 p.m | | 28/4/21 | | | |
| Sencillo | | Estelí vs. Dantos | | 01:00 p.m | | 28/4/21 | | | |
| Sencillo | | Zelaya Central vs. Granada | | 11:00 a.m | | 05/5/21 | | | |
| Sencillo | | Jinotega vs. Nueva Segovia | | 11:00 a.m | | 05/5/21 | | | |
| J1 | | Dantos vs. Estelí | | 01:00 p.m | | 05/5/21 | | | |
| J2 | | Dantos vs. Estelí | | 05:00 p.m | | 05/5/21 | | | |
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(CNBS – GPO 2021)
Managua, martes 20 de abril 2021.
Ciudad Deportiva 