Jornada 24 de Abril
| J1 | | Zelaya Central vs CostaCaribe | | 01:00 p.m. | | 24/4/21 | | | |
| J1 | | Dantos vs Jinotega | | 03:30 p.m | | 24/4/21 | | | |
| J2 | | Dantos vs Jinotega | | 06:30 p.m | | 24/4/21 | | | |
| J1 | | Masaya vs León | | 01:00 p.m | | 24/4/21 | | | |
| J2 | | Masaya vs León | | 05:00 p.m | | 24/4/21 | | | |
| J1 | | Chinandega vs Estelí | | 01:00 p.m | | 24/4/21 | | | |
| J2 | | Chinandega vs Estelí | | 05:00 p.m | | 24/4/21 | | | |
| J1 | | Río San Juan vs Boer | | 10:00 a.m | | 24/4/21 | | | |
| J2 | | Río San Juan vs Boer | | 01:00 p.m | | 24/4/21 | | | |
| J1 | | Carazo vs Madriz | | 01:00 p.m | | 24/4/21 | | | |
| J2 | | Carazo vs Madriz | | 05:00 p.m | | 24/4/21 | | | |
| J1 | | Matagalpa vs Nueva Segovia | | 01:00 p.m | | 24/4/21 | | | |
| J2 | | Matagalpa vs Nueva Segovia | | 05:00 p.m | | 24/4/21 | | | |
| J1 | | Chontales vs Granada | | 01:00 p.m | | 24/4/21 | | | |
| J2 | | Chontales vs Granada | | 05:00 p.m | | 24/4/21 | | | |
| J1 | | Rivas vs Boaco | | 01:00 p.m | | 24/4/21 | | | |
| J2 | | Rivas vs Boaco | | 05:00 p.m | | 24/4/21 | | | |
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Ciudad Deportiva 